Crew-8 will conduct new scientific research to prepare for human exploration beyond low Earth orbit and benefit humanity on Earth. Experiments include using stem cells to create organoid models to study degenerative diseases, studying the effects of microgravity and UV radiation on plants at a cellular level, and testing whether wearing pressure cuffs on the legs could prevent fluid shifts and reduce health problems in astronauts. SpaceX Dragon and Roscosmos Progress cargo spacecraft will also launch during their stay.