In a recent review published in the journal The Lancet Healthy Longevity, researchers collated the outcomes of 130 observational studies. Their findings present that both frailty (reduced physiological reserve) and social vulnerability (insufficient social interactions, support, or connections) worsen with increasing age. When present together, these conditions result in a significantly increased decline in physical and cognitive function and mortality risk. This compromises the ability to cope with everyday or acute stressors.