The Patient-Centered Outcomes Research Institute (PCORI) announced the approval of funding awards totaling more than $150 million to support new patient-centered comparative clinical effectiveness research (CER) studies. The awards include support for large, two-phased trials comparing approaches to treatments for heart failure and asthma. This latest round of PCORI funding awards also includes CER studies exploring questions about the value of screening for financial hardship to improve patient outcomes for individuals with advanced cancer.