The Africa Centres for Disease Control and Prevention kicked-off two groundbreaking projects. These initiatives are poised to fortify the Africa Pathogen Genomics Initiative (Africa PGI 2.0), enhancing the capacity of member states for molecular detection of outbreaks, AMR genomic surveillance, and timely data sharing across Africa. Through these projects, Africa CDC and HERA, in partnership with African Union Member States, the African Society for Laboratory Medicine (ASLM) and the African Public Health Foundation (APHF), will strengthen national and regional